Tretinoin has become one of the most talked about ingredients in skincare, recommended by dermatologists and featured in countless skincare routines. But what exactly is tretinoin, how does it work and why has it gained such popularity?
What Is Tretinoin?
Tretinoin is a prescription-strength retinoid, a derivative of vitamin A used primarily in skincare to treat acne, reduce signs of ageing and improve overall skin texture.
Unlike over-the-counter retinol products, tretinoin is stronger and more potent because it does not require conversion by the skin to become active. It works directly at the cellular level, making it a highly effective solution for a range of skin concerns.
Tretinoin has been used for decades, but its popularity has surged in recent years as more people seek evidence-based solutions for clear and radiant skin.
The Science Behind Tretinoin
When applied to the skin, tretinoin binds to retinoic acid receptors in skin cells. This interaction triggers a cascade of cellular changes:
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Increases cell turnover – old, dead skin cells are replaced faster
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Unclogs pores – reduces acne formation
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Stimulates collagen production – improves firmness and elasticity
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Improves pigmentation – helps fade dark spots and even skin tone
Over time, these biological effects can significantly improve the appearance and health of your skin.
Who Should Use Tretinoin?
Tretinoin is used by a wide range of people, including:
Acne-Prone Skin
Tretinoin is one of the most prescribed acne treatments because it helps prevent clogged pores and promotes skin turnover.
Concerns with Ageing
Fine lines, wrinkles and uneven texture are all targets of tretinoin, boosting collagen and cell turnover.
Uneven Skin Tone
Hyperpigmentation, dark spots and post-inflammatory marks respond well to sustained use.
Wanting Clearer, Healthier Skin
Even people with generally healthy skin use tretinoin for maintenance and prevention.
Top Benefits of Tretinoin
Clears Acne and Prevents Breakouts
Tretinoin keeps pores clear by accelerating how quickly skin cells are replaced, stopping dead cells from clogging follicles which may be a cause of acne.
Reduces Fine Lines and Wrinkles
By stimulating collagen production over time, tretinoin improves skin elasticity and smoothness, making it a favourite anti-ageing ingredient.
Fades Dark Spots and Discolouration
Hyperpigmentation and sun damage improve because tretinoin promotes regeneration of skin cells.
Improves Skin Texture
Rough patches, uneven tone and dullness become smoother and more radiant with consistent use.
Long-Term Benefits
Tretinoin isn’t a quick-fix, its strength lies in sustained improvement with continued use.
How to Use Tretinoin Safely
Because tretinoin is powerful, appropriate usage is key to getting results while minimising irritation.
Step-by-Step Guide
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Cleanse Gently
Use a mild, non-stripping cleanser. -
Dry Skin Thoroughly
Tretinoin can be more irritating on damp skin. -
Apply a Pea-Size Amount
A thin layer is all you need, more does not mean better results. -
Moisturise After
A soothing moisturiser reduces irritation and dryness. -
Use at Night Only
Sunlight deactivates tretinoin and increases sensitivity. -
Apply SPF Every Morning (and reapply)
Daily SPF 30+ is critical, tretinoin makes skin more susceptible to UV damage.
Introducing Tretinoin Slowly
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Start with every other night
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Observe how your skin reacts
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Increase frequency as tolerated
This gentle introduction helps your skin adapt without severe peeling or redness.
Potential Side Effects and How to Manage Them
With great efficacy comes a possibility of irritation, especially at first. Common side effects include:
Dryness and Flaking
Use a rich moisturiser and consider sandwiching with your moisturiser before application.
Redness
This is common in early weeks. Avoid harsh scrubs, exfoliants and strong acids while your skin adjusts.
Sensitivity to Sunlight
Tretinoin increases photosensitivity, sunscreen is essential!
If irritation persists beyond the first few weeks, speak with a dermatologist or our skin concierge. Often, adjusting frequency or using a lower concentration helps significantly.
Tretinoin vs Retinol: What’s the Difference?
Retinol
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Available over-the-counter
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Must convert to retinoic acid inside the skin
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Gentler but slower and less potent
Tretinoin
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Prescription-strength
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Already in active form
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Faster and more powerful results
Retinol is great for beginners or sensitive skin while tretinoin delivers stronger results under professional guidance.
Tretinoin’s popularity is rooted in science, effectiveness and real-life results. From clearing acne to improving signs of ageing and renewing skin texture, it’s a powerful tool in modern skincare. Tretinoin works best when used properly along with patience, protection from the sun and guidance from a skincare professional.
If you’re curious about tretinoin and whether it’s right for your skin, here at Skin Pharmacy, we can help determine the best strength and routine for you.
If you have any specific questions on Tretinoin, speak to our experts - for free. Book an appointment online here. Alternatively, email hello@skinpharmacy.com or call us on 020 3070 3833 or 07522 002050.
